[1]迟曰梅,罗丹,李彩霞,等.单侧多灶性甲状腺癌临床病理特点和手术方式比较[J].齐鲁医学杂志,2017,32(06):649-652.[doi:10.13362/j.qlyx.201706006]
 CHI Yuemei,LUO Dan,LI Caixia,et al.CLINICOPATHOLOGICAL FEATURES AND SURGICAL PROCEDURES OF UNILATERAL MULTIFOCAL THYROID CARCINOMA[J].Medical Journal of Qilu,2017,32(06):649-652.[doi:10.13362/j.qlyx.201706006]
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单侧多灶性甲状腺癌临床病理特点和手术方式比较()
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《齐鲁医学杂志》[ISSN:1008-0341/CN:37-1280/R]

卷:
第32卷
期数:
2017年06期
页码:
649-652
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
CLINICOPATHOLOGICAL FEATURES AND SURGICAL PROCEDURES OF UNILATERAL MULTIFOCAL THYROID CARCINOMA
文章编号:
1008-0341(2017)06-0649-04
作者:
迟曰梅1罗丹1李彩霞2王新超2
1 天津医科大学研究生院,天津 300070; 2 天津市第四中心医院甲状腺乳腺外科
Author(s):
CHI Yuemei LUO Dan LI Caixia WANG Xinchao
Tianjin Medical University Graduate School, Tianjin 300070, China
关键词:
甲状腺肿瘤甲状腺切除术颈淋巴结清扫术肿瘤复发局部
Keywords:
thyroid neoplasms thyroidectomy neck dissection neoplasm recurrence local
分类号:
R736.1
DOI:
10.13362/j.qlyx.201706006
文献标志码:
A
摘要:
目的 研究单侧多灶性甲状腺乳头状癌(MPTC)的临床病理特点,并了解单侧MPTC不同手术方式治疗的效果。
方法 比较单侧MPTC(127例)和双侧MPTC(80例)病人的临床特点;将单侧MPTC病人分为全甲状腺切除术组(70例)和甲状腺部分切除术组(57例),比较两组术中及术后情况,分析术后复发或转移的危险因素。
结果 单侧MPTC的临床病理因素与双侧MPTC相比,差异无统计学意义(P>0.05)。单侧MPTC不同方式手术组的手术时间差异有显著性(t=9.063,P<0.05)。多因素分析示,甲状腺包膜侵犯(OR=26.392,95%CI=2.373~344.254,P<0.05)和手术方式(OR=0.041,95%CI=0.003~0.436,P<0.05)是单侧MPTC术后复发的独立危险因素。
结论 单侧MPTC的临床病理因素与双侧MPTC相比无差异;甲状腺全切除术可以有效降低单侧MPTC术后复发或转移率,尤其对癌灶侵出包膜病人。
Abstract:
Objective  To investigate the clinicopathological features of unilateral multifocal papillary thyroid carcinoma (MPTC) and the therapeutic effects of different surgical procedures on unilateral MPTC.
Methods  Clinical features were compared between patients with unilateral MPTC (127 patients) and those with bilateral MPTC (80 patients). The patients with unilateral MPTC were divided into total thyroidectomy group (70 patients) and partial thyroidectomy group (57 patients), and the two groups were compared in terms of intraoperative and postoperative conditions and risk factors for postoperative recurrence or metastasis.
Results  There were no significant differences in clinicopathological features between the patients with unilateral MPTC and those with bilateral MPTC (P>0.05). There was a significant difference in the time of operation between the total thyroidectomy group and the partial thyroidectomy group (t=9.063,P<0.05). The multivariate analysis showed that thyroid extracapsular extension (odds ratio (OR)=26.392,95% confidence interval (CI)=2.373-344.254,P<0.05) and surgical procedure (OR=0.041,95% CI=0.003-0.436,P<0.05) were independent risk factors for the postoperative recurrence of unilateral MPTC.
Conclusion  There are no significant differences in clinicopathological features between the patients with unilateral MPTC and those with bilateral MPTC. Total thyroidectomy can effectively reduce the postoperative recurrence or metastasis rate of unilateral MPTC, especially in patients with thyroid extracapsular extension.
更新日期/Last Update: 2018-03-24