[1]韩建建,王青山,袁琛,等.双硫仑样反应病人58例临床分析[J].齐鲁医学杂志,2017,32(06):704-706,710.[doi:10.13362/j.qlyx.201706021]
 HAN Jianjian,WANG Qingshan,YUAN Chen,et al.FEATURES OF DISULFIRAM-LIKE REACTION: A CLINICAL ANALYSIS OF 58 CASES[J].Medical Journal of Qilu,2017,32(06):704-706,710.[doi:10.13362/j.qlyx.201706021]
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双硫仑样反应病人58例临床分析()
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《齐鲁医学杂志》[ISSN:1008-0341/CN:37-1280/R]

卷:
第32卷
期数:
2017年06期
页码:
704-706,710
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
FEATURES OF DISULFIRAM-LIKE REACTION: A CLINICAL ANALYSIS OF 58 CASES
文章编号:
1008-0341(2017)06-0704-04
作者:
韩建建王青山袁琛谢东方
青岛市中心医院急诊科,山东 青岛 266042
Author(s):
HAN Jianjian WANG Qingshan YUAN Chen XIE Dongfang
Emergency Department, Qingdao Central Hospital, Qingdao 266042, China
关键词:
双硫仑药物相关性副作用和不良反应头孢菌素类硝基咪唑类乙醇
Keywords:
disulfiram drug-related side effects and adverse reactions cephalosporins nitroimidazoles ethanol
分类号:
R595.3
DOI:
10.13362/j.qlyx.201706021
文献标志码:
A
摘要:
目的 分析双硫仑样反应发生的特点、分布及其发生的危险因素,为双硫仑样反应预防提供依据。
方法 回顾性分析我院2013年1月—2016年12月收治的58例双硫仑样反应病人临床资料,总结其发生原因、流行病学特点、临床特征及急救措施。
结果 双硫仑样反应主要发生于31~50岁中青年人,男性发病率明显高于女性,差异有显著性(χ2=31.270,P<0.05);其发生原因与使用头孢菌素类药物、硝基咪唑类药物及饮酒或服用含乙醇制品等有关;其不良反应涉及皮肤、循环系统、消化系统、呼吸系统和神经系统等,主要表现为皮肤潮红、恶心呕吐、心动过速、头痛头晕等,严重者表现为呼吸困难、血压下降、神志不清、昏迷等。58例病人经积极抢救治疗,30~180 min症状缓解,无死亡病例。
结论 应用头孢菌素类、硝基咪唑类药物病人用药过程中及停药后1周内禁止服用含乙醇制品。
Abstract:
Objective  To investigate the features, distribution, and risk factors of disulfiram-like reaction, and to provide a reference for the prevention of disulfiram-like reaction.
Methods  A retrospective analysis was performed for the clinical data of 58 patients with disulfiram-like reaction who were admitted to our hospital from January 2013 to December 2016 to summarize its causes, epidemiological features, clinical features, and emergency treatment measures.
Results  Disulfiram-like reaction mainly occurred in young and middle-aged adults aged 31-50 years, and men had a significantly higher incidence rate than women (χ2=31.270,P<0.05). The development of disulfiram-like reaction was associated with the application of cephalosporins and nitroimidazoles and drinking or eating alcohol-containing products. Its adverse reactions involved the skin, circulatory system, digestive system, respiratory system, and nervous system, with major manifestations of skin flushing, nausea and vomiting, tachycardia, headache, and dizziness, even dyspnea, reduced blood pressure, unconsciousness, and coma in patients with severe conditions. All patients were given active rescue, and the symptoms were relieved after 30-180 min. No patient died.
Conclusion  Patients who take cephalosporins and nitroimidazoles should not eat or drink alcohol-containing products during administration and within 1 week after drug withdrawal.
更新日期/Last Update: 2018-03-24