[1]冯晓丽,何杰,李万成,等.FAM13A基因多态性与慢性阻塞性肺疾病易感性关系的Meta分析[J].齐鲁医学杂志,2017,32(03):315-318,320.[doi:10.13362/j.qlyx.201703020]
 FENG Xiaoli,HE Jie,LI Wancheng,et al.ASSOCIATION BETWEEN FAM13A GENE POLYMORPHISM AND THE RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A META-ANALYSIS[J].Medical Journal of Qilu,2017,32(03):315-318,320.[doi:10.13362/j.qlyx.201703020]
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FAM13A基因多态性与慢性阻塞性肺疾病易感性关系的Meta分析()
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《齐鲁医学杂志》[ISSN:1008-0341/CN:37-1280/R]

卷:
第32卷
期数:
2017年03期
页码:
315-318,320
栏目:
出版日期:
2017-08-07

文章信息/Info

Title:
ASSOCIATION BETWEEN FAM13A GENE POLYMORPHISM AND THE RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A META-ANALYSIS
文章编号:
1008-0341(2017)03-0315-05
作者:
冯晓丽何杰李万成李小燕任召强
成都医学院第一附属医院呼吸内科,四川 成都 610500
Author(s):
FENG Xiaoli HE Jie LI Wancheng LI Xiaoyan REN Zhaoqiang
Department of Respiratory Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China
关键词:
家族序列相似性13A基因肺疾病慢性阻塞性多态性单核苷酸Meta分析
Keywords:
family sequence similarity 13A gene chronic obstructive pulmonary disease polymorphism single nucleotide meta-analysis
分类号:
R563.9
DOI:
10.13362/j.qlyx.201703020
文献标志码:
A
摘要:
目的 采用Meta分析的方法综合评价家族序列相似性13A(FAM13A)基因rs7671167位点多态性与慢性阻塞性肺疾病(COPD)的关系。
方法 计算机检索PubMed、CNKI、万方、EMbase等数据库有关FAM13A基因rs7671167位点多态性与COPD发病风险的病例-对照研究,检索时间范围从建库至2016年6月20日。由两位研究者按照已制定的标准纳入文献并进行文献质量评价及资料提取。采用RevMan 5.3软件进行Meta分析。
结果 共纳入研究文献7篇,包括COPD组3 571例,对照组4 344例。Meta分析结果显示,在总体人群中,FAM13A基因rs7671167位点多态性与COPD易感性相关(CC+CT vs.TT,OR=0.76,95%CI=0.62~0.94,P<0.05);将人群按照种族不同进行分层分析,未发现FAM13A基因rs7671167位点多态性与亚洲人群COPD发病风险相关(CC+CT vs.TT,OR=0.82,95%CI=0.64~1.05,P>0.05);但在高加索人群中,FAM13A基因rs7671167位点多态性与COPD易感性相关(CC+CT vs.TT,OR=0.63,95%CI=0.43~0.93,P<0.05)。
结论 FAM13A基因rs7671167位点多态性与高加索人群COPD发病风险具有相关性,可能降低高加索人群COPD发病风险;尚不能确定FAM13A基因rs7671167位点及等位基因基因型与亚洲人群COPD发病风险相关。
Abstract:
Objective  To comprehensively evaluate the association of FAM13A gene polymorphism with chronic obstructive pulmonary disease (COPD) applying a meta-analysis.
Methods  A computer search of case-control studies regarding correlation between FAM13A gene polymorphism and COPD in PubMed,CNKI, WanFang and EMbase database was conducted. The retrieval time range was from the day of building database to June 20, 2016. In accordance with established standards, the literature was included, evaluated and data extracted by two reviewers. A Meta-analysis was done adopting RevMan 5.3 software.
Results  A total of seven studies involving 3 571 COPD cases and 4 344 healthy controls were included. The Meta-analysis demonstrated that COPD susceptibility was correlated with FAM13A rs7671167 polymorphism (CC+CT vs.TT: OR=0.76,95%CI=0.62-0.94,P<0.05). In the subgroup analysis by ethnicity, significant decreased risk of COPD was found in the Caucasian C allele carriers (CC+CT vs.TT: OR=0.63,95%CI=0.43-0.93,P<0.05), but not in Asian (CC+CT vs.TT: OR=0.82,95%CI=0.64-1.05,P>0.05).
Conclusion  FAM13A gene rs7671167 polymorphism is correlated with susceptibility of COPD in Caucasian, which may decrease the onset risk of COPD in Caucasian, but the correlation of risk of COPD with FAM13A gene rs7671167 polymorphism in Asian is still not sure.
更新日期/Last Update: 2017-08-12