[1]孙绍婷,邢广群,栾军军.特发性膜性肾病治疗反应影响因素分析[J].齐鲁医学杂志,2017,32(03):342-344.[doi:10.13362/j.qlyx.201703029]
 SUN Shaoting,XING Guangqun,LUAN Junjun.INFLUENCING FACTORS FOR TREATMENT RESPONSE OF IDIOPATHIC MEMBRANOUS NEPHROPATHY[J].Medical Journal of Qilu,2017,32(03):342-344.[doi:10.13362/j.qlyx.201703029]
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特发性膜性肾病治疗反应影响因素分析()
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《齐鲁医学杂志》[ISSN:1008-0341/CN:37-1280/R]

卷:
第32卷
期数:
2017年03期
页码:
342-344
栏目:
出版日期:
2017-08-07

文章信息/Info

Title:
INFLUENCING FACTORS FOR TREATMENT RESPONSE OF IDIOPATHIC MEMBRANOUS NEPHROPATHY
文章编号:
1008-0341(2017)03-0342-03
作者:
孙绍婷邢广群栾军军
青岛大学附属医院黄岛院区肾病科,山东 青岛 266500
Author(s):
SUN Shaoting XING Guangqun LUAN Junjun
Nephrology of Huangdao, The Affiliated Hospital of Qingdao University, Qingdao 266500, China
关键词:
肾小球肾炎膜性脂蛋白类HDL肌酐治疗结果影响因素分析
Keywords:
glomerulonephritis membranous lipoproteins HDL creatinine treatment outcome root cause analysis
分类号:
R692.31
DOI:
10.13362/j.qlyx.201703029
文献标志码:
A
摘要:
目的 探讨特发性膜性肾病治疗反应的影响因素。
方法 收集2011年9月—2016年5月我院黄岛院区经肾穿刺活检明确诊断、能够规律门诊随访至少6个月的57例特发性膜性肾病病人的临床资料,根据治疗后24 h尿蛋白水平的变化,分为缓解组和未缓解组,对影响特发性膜性肾病治疗反应的因素进行分析。
结果 特发性膜性肾病未缓解组病人初始治疗时血清脂蛋白α及肌酐水平明显高于缓解组(t=-2.218、-2.495,P<0.05)。单因素Logistic回归分析显示,初始治疗时血清脂蛋白α水平(OR=1.002,95%CI=1.001~1.004,P<0.05)及肌酐水平(OR=1.036,95%CI=1.000~1.078,P<0.05)是影响膜性肾病治疗反应的危险因素。多因素Logistic回归分析显示,初始治疗时血清脂蛋白α水平(OR=1.002,95%CI=1.000~1.004,P<0.05)与肌酐水平(OR=1.044,95%CI=1.004~1.086,P<0.05)是影响膜性肾病治疗反应的独立危险因素。
结论 初始治疗时血清脂蛋白α和肌酐水平是影响特发性膜性肾病治疗反应的独立危险因素。
Abstract:
Objective  To investigate the influencing factors for the treatment response of idiopathic membranous nephropathy.
Methods  A total of 57 patients who were diagnosed with idiopathic membranous nephropathy by renal biopsy and followed up for at least 6 months in Huangdao Branch of our hospital from September 2011 to May 2016 were enrolled and their clinical data were collected. According to the changes in 24 h urinary protein excretion after treatment, the patients were divided into remission group and non-remission group. The influencing factors for the treatment response of idiopathic membranous nephro-
pathy were analyzed.
Results  The non-remission group had significantly higher serum levels of lipoprotein α and creatinine at the time of initial treatment (t=-2.218,-2.495;P<0.05). The univariate logistic regression analysis showed that serum levels of lipoprotein α (OR=1.002,95%CI=1.001-1.004,P<0.05) and creatinine (OR=1.036,95%CI=1.000-1.078,P<0.05) at the time of initial treatment were influencing factors for the treatment response of idiopathic membranous nephropathy. The multivariate logistic regression analysis showed that serum levels of lipoprotein α (OR=1.002,95%CI=1.000-1.004,P<0.05) and creatinine (OR=1.044,95%CI=1.004-1.086,P<0.05) at the time of initial treatment were independent risk factors for the treatment response of idiopathic membranous nephropathy.
Conclusion  Serum levels of lipoprotein α and creatinine at the time of initial treatment are independent risk factors for the treatment response of idiopathic membranous nephropathy.
更新日期/Last Update: 2017-08-12