[1]林立娟,余娜,梁爱华,等.过氧化物还原酶3在子宫内膜癌组织表达及意义[J].齐鲁医学杂志,2017,32(06):642-645.[doi:10.13362/j.qlyx.201706004]
 LIN Lijuan,YU Na,LIANG Aihua,et al.EXPRESSION OF PEROXIREDOXIN 3 IN ENDOMETRIAL CARCINOMA TISSUE AND ITS CLINICAL SIGNIFICANCE[J].Medical Journal of Qilu,2017,32(06):642-645.[doi:10.13362/j.qlyx.201706004]
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过氧化物还原酶3在子宫内膜癌组织表达及意义()
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《齐鲁医学杂志》[ISSN:1008-0341/CN:37-1280/R]

卷:
第32卷
期数:
2017年06期
页码:
642-645
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
EXPRESSION OF PEROXIREDOXIN 3 IN ENDOMETRIAL CARCINOMA TISSUE AND ITS CLINICAL SIGNIFICANCE
文章编号:
1008-0341(2017)06-0642-04
作者:
林立娟12余娜2梁爱华2李连芹3
1 滨州医学院妇产科学教研室,山东 烟台 264003; 2 德州市立医院妇科; 3 滨州医学院烟台附属医院妇产科
Author(s):
LIN Lijuan YU Na LIANG Aihua LI Lianqin
Department of Obstetrics and Gynecology, Binzhou Medical University, Yantai 264003, China
关键词:
子宫内膜肿瘤氧化性应激过氧化物还原酶3
Keywords:
endometrial neoplasms oxidative stress peroxiredoxin 3
分类号:
R737.33
DOI:
10.13362/j.qlyx.201706004
文献标志码:
A
摘要:
目的 探讨过氧化物还原酶3在子宫内膜癌中的表达及临床意义。
方法 选取2016年10月—2017年5月在我院接受治疗的子宫内膜癌病人共30例,采用免疫组化染色检测过氧化物还原酶3在子宫内膜癌组织中的表达,采用酶联免疫吸附试验法检测病人血清中过氧化物还原酶3的水平,并与同期入院的30例良性病变病人(对照组)进行比较。分析子宫内膜癌病人血清及癌组织中过氧化物还原酶3表达的相关性。
结果 过氧化物还原酶3在子宫内膜癌病人血清及癌组织中的表达均高于对照组,差异有统计学意义(t=2.198、2.819,P<0.05),但其在子宫内膜癌病人血清及癌组织中的表达无相关性。子宫内膜癌病人血清雌二醇和胰岛素水平显著高于对照组(t=2.211、2.905,P<0.05)。
结论 子宫内膜癌组织中过氧化物还原酶3的表达升高可能与其局部的氧化应激状态有关,其表达上调可能有助于促进肿瘤细胞的生长;而病人血清中过氧化物还原酶3水平升高,可能与其胰岛素水平升高有关。
Abstract:
Objective  To investigate the expression of peroxiredoxin 3 in endometrial carcinoma and its clinical significance.
Methods  A total of 30 endometrial carcinoma patients treated in our hospital from October 2016 to May 2017 were selected in this study. The expression of peroxiredoxin 3 in endometrial carcinoma was measured by immunohistochemical staining. The serum level of peroxiredoxin 3 was determined by enzyme-linked immunosorbent assay (ELISA). The expression of peroxiredoxin 3 in endometrial carcinoma and the level of peroxiredoxin 3 in serum were compared with those of the control patients with benign lesions who were hospitalized in the same period. The correlation between the peroxiredoxin 3 expression levels in the serum and cancer tissues of patients with endometrial carcinoma was analyzed.
Results  The expression levels of peroxiredoxin 3 in the serum and cancer tissues of patients with endometrial carcinoma were significantly higher than those of the control group (t=2.198 and 2.819, both P<0.05). No correlation was found between the expression of peroxiredoxin 3 in serum and cancer tissues in the patients with endometrial carcinoma. In addition, the serum estradiol and insulin levels were significantly higher in the endometrial carcinoma patients than in the control group (t=2.211 and 2.905, both P<0.05).
Conclusion  The elevated expression of peroxiredoxin 3 in endometrial carcinoma tissue may be related to the local oxidative stress status in cancer tissue. The up-regulation of peroxiredoxin 3 may contribute to the growth of tumor cells. The elevated level of peroxiredoxin 3 in serum may be related to the elevated insulin level in patients.
更新日期/Last Update: 2018-03-24