[1]曲文文,闫慧,王燕,等.不同危险分层原发性高血压病人健康子女血浆AM、AngⅡ及ET水平的变化[J].齐鲁医学杂志,2017,32(06):697-699.[doi:10.13362/j.qlyx.201706019]
 QU Wenwen,YAN Hui,WANG Yan,et al.CHANGES IN ADRENOMEDULLIN, ANGIOTENSIN Ⅱ, AND ENDOTHELIN IN HEALTHY OFFSPRING WITH A FAMILY HISTORY OF ESSENTIAL HYPERTENSION WITH DIFFERENT RISK STRATIFICATIONS[J].Medical Journal of Qilu,2017,32(06):697-699.[doi:10.13362/j.qlyx.201706019]
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不同危险分层原发性高血压病人健康子女血浆AM、AngⅡ及ET水平的变化()
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《齐鲁医学杂志》[ISSN:1008-0341/CN:37-1280/R]

卷:
第32卷
期数:
2017年06期
页码:
697-699
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
CHANGES IN ADRENOMEDULLIN, ANGIOTENSIN Ⅱ, AND ENDOTHELIN IN HEALTHY OFFSPRING WITH A FAMILY HISTORY OF ESSENTIAL HYPERTENSION WITH DIFFERENT RISK STRATIFICATIONS
文章编号:
1008-0341(2017)06-0697-03
作者:
曲文文1闫慧1王燕2傅增泮1
青岛大学附属医院,山东 青岛 266003 1 心内科; 2 体检中心
Author(s):
QU Wenwen YAN Hui WANG Yan FU Zengpan
Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
关键词:
高血压危险因素肾上腺髓质素血管紧张素Ⅱ内皮素
Keywords:
hypertension risk factors adrenomedullin angiotensin Ⅱ endothelin
分类号:
R544.11;R347.92
DOI:
10.13362/j.qlyx.201706019
文献标志码:
A
摘要:
目的 了解不同危险分层原发性高血压(EH)病人健康子女血浆肾上腺髓质素(AM)、血管紧张素Ⅱ(AngⅡ)及内皮素(ET)的水平,探讨其在高血压发生、发展中的作用,为高血压的一级预防及治疗提供新的思路与方法。
方法 随机选择来我院查体中心查体、有EH家族史的健康子女80例为实验组,根据《2004年WHO/ISH高血压诊疗指南》将不同危险分层双亲的健康子女分为低危、中危、高危及极高危组4个亚组,以双亲均无高血压的健康子女20例为对照组。采用放射免疫法测定各组血浆AM、AngⅡ及ET的水平。
结果 实验组血浆AM、AngⅡ及ET水平均高于对照组,差异有显著性(F=44.70~90.76,q=13.08~39.78,P<0.05),各亚组间比较差异均有显著性(q=21.33~96.65,P<0.05)。实验组血浆AngⅡ与AM、ET水平呈正相关(r=0.765、0.687,P<0.01)。
结论 有EH家族史的健康子代在高血压出现之前AM、AngⅡ和ET水平已经升高,且随双亲心血管危险分层的增高而增加。受遗传因素的影响这些血管活性物质可能参与了EH的发生与发展,这为高血压的预防和治疗提供了参考依据。
Abstract:
Objective  To investigate the plasma levels of adrenomedullin (AM), angiotensin Ⅱ (Ang Ⅱ), and endothelin (ET) in healthy offspring with a family history of essential hypertension (EH) with different risk stratifications, as well as their roles in the development and progression of hypertension, and to provide a new method for the primary prevention and treatment of hypertension.
Methods  This study included 80 healthy offspring randomly selected from the individuals who underwent physical examinations in the Physical Examination Center of our hospital and who had a family history of EH. These subjects were divided into low-risk group, medium-risk group, high-risk group, and extremely high-risk group according to their parents’ risk stratification based on the 2004 WHO/ISH hypertension guidelines. Twenty individuals without a family history of EH were enrolled as control group. The plasma levels of AM, Ang Ⅱ, and ET were determined by radioimmunoassay.
Results  The plasma levels of AM, Ang Ⅱ, and ET were significantly higher in the low-risk group, medium-risk group, high-risk group, and extremely high-risk group than in the control group (F=44.70-90.76,q=13.08-39.78,P<0.05), and they were significantly different between the low-risk group, medium-risk group, high-risk group, and extremely high-risk group (q=21.33-96.65,P<0.05). Among the subjects in the low-risk group, medium-risk group, high-risk group, and extremely high-risk group, plasma Ang Ⅱ level was positively correlated with the plasma levels of AM and ET (r=0.765 and 0.687,P<0.01).
Conclusion  The levels of AM, Ang Ⅱ, and ET rise in the healthy offspring with a family history of EH before the development of hypertension, and increase as their parents’ risk stratification increases. It is suggested that these vasoactive substances may be involved in the development and progression of EH because of hereditary factors, which provides a reference for the prevention and treatment of EH.
更新日期/Last Update: 2018-03-24